DIGESTIVE DISEASE WEEK 2007: Summary of Presented Abstracts

Click on the image for access to the data presented at DDW 2007.

At DDW 2007, 13 scientific abstracts were presented that are related to clinical trials conducted with the HALO ablation systems over the past 4 years. These presentations further add to a growing body of evidence and experience for this intervention in treating a patient with Barrett's esophagus. The following is a selected summary of the presentations: Long-term (2.5 years) follow-up results of the AIM Trial (Ablation of Intestinal Metaplasia) was reported for the first time. The 1-year follow-up results were recently published in Gastrointestinal Endoscopy in which 70% of patients demonstrated complete histological resolution of all IM after treatment with the HALO360 device. After adding the HALO90 focal ablation device to the treatment protocol and extending the study follow-up to 2.5-years, the complete response rate has increased to 98.4%11,12 A study showing that ablation with the HALO System for Barrett's containing HGD +/- early cancer eradicated all baseline genetic abnormalities20 A cost-effectiveness analysis comparing a surveillance strategy versus ablation for Barrett's containing LGD demonstrated superiority of the ablation strategy21 A U.S. HGD Registry reported complete response of IM in 90% of the HGD patients after ablation using the HALO system22 The AIM-LGD trial demonstrated that 100% of treated patients had no evidence of dysplasia at 2 year follow-up, and that 90% had no evidence of IM23 A study showed that combining endoscopic mucosal resection followed by ablation can be safely performed and eradicate Barrett's containing HGD +/- early cancer24 Physicians at the Academic Medical Center in Amsterdam demonstrated that the optimal technique for circumferential ablation has evolved and there is a significant difference in efficacy outcomes25 A U.S. Registry reporting on the use of the HALO90 focal ablation device demonstrated safety and patient tolerability (in both a community and academic setting) in 508 cases performed in 200626

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