WHY TREAT BARRETT'S ESOPHAGUS?29
Barrett's esophagus is a precancerous condition that can, in some individuals, lead to the development
of high-grade dysplasia and esophageal adenocarcinoma.
Progression of Intestinal Metaplasia to Low-Grade Dysplasia,
High-Grade Dysplasia and Cancer
| Diagnosis |
%
of Risk in
4 Years |
%
of Risk
per Year |
|
| |
|
|
|
| |
Intestinal metaplasia advancing to low-grade dysplasia |
16.1% |
4.3% |
| |
Intestinal metaplasia advancing to high-grade dysplasia |
3.6% |
0.9% |
| |
Intestinal metaplasia advancing to esophageal adenocarcinoma |
2.0% |
0.5% |
| |
|
|
|
|
|
| Data obtained from Sharma P, Falk GW, Weston AP, et al. Dysplasia and cancer in a large multicenter cohort of patients with Barrett’s esophagus. Clin Gastroenterol Hepatol 2006; 4:566-572.
|
Patients with intestinal metaplasia have a combined risk of 1.4% per year of progressing to high-grade dysplasia or cancer, which may result in an esophagectomy procedure.
References
